CRISPRa-dCas9

Innovative treatment for uterine carcinosarcoma patients using CRISPRa technology.

What is CRISPRa-dCas9?

It is a revolutionary gene editing enzyme that can upregulate certain genes in the body. In our case, the complex is introduced into the body via lipid nanoparticle. Once inside the target cell, a guide RNA will direct the Cas-9 enzyme to the target gene HS3BD1.

What does it do?

An upregulation of HS3BD1 will increase progesterone production, which will then slow down and minimize tumor growth by outcompeting estrogen in the body

Why Progesterone?

Testing Mechanism

We plan on using ELISA (an already well researched testing platform) to ensure that our therapeutic is working effectively for each of our patients.

Progesterone is a naturally occuring hormone in the body that helps prepare the uterus for a fetus and promotes the shedding of the uterine lining. One of progesterone's biggest advantages to the cancer fight is its ability to outcompete estrogen, which is another hormone that fuels cancer growth. By limiting estrogen, we can limit tumor growth using the body's natural hormones.